The Shocking Rise of IgG4
This explains so much about the corresponding rise of illnesses in the West.
Are We Training Our Immune System to Surrender? The Shocking Rise of IgG4 After Pfizer’s mRNA Vaccination
Staff at TrialSite | Quality Journalism
Feb. 17, 2025, 6:00 a.m.
A New Twist in Immunity? A striking new study led by scientists at King’s College London challenges conventional assumptions about how our immune system responds to repeated mRNA vaccination. And it’s not the first, but one of many of similar outcomes tracked by TrialSite News. While we expect vaccines to enhance our ability to fight off viruses, emerging data suggests that multiple doses of the BNT162b2 mRNA vaccine (Pfizer-BioNTech) are causing an unusual shift in antibody responses—one that leans toward immune tolerance rather than active defense.
The Study
The study zeroes in on IgG4 antibodies, a subclass typically associated with desensitization in allergy therapies, not viral immunity. After repeated mRNA vaccinations, researchers observed a marked increase in IgG4 levels, a phenomenon not seen after natural infection or with vector-based vaccines like AstraZeneca. This unexpected shift raises urgent questions: namely, could this change in antibody profile alter the long-term effectiveness of mRNA vaccines? And does it have implications beyond COVID-19?
Dampened Immunity? The Functional Impact of IgG4
Unlike the more aggressive IgG1 and IgG3 antibodies, which efficiently neutralize pathogens and activate immune responses, IgG4 has a reduced capacity to engage immune defenses. The study found that elevated IgG4 levels:
• Weaken key immune functions such as complement activation and antibody-dependent cell-mediated cytotoxicity, both of which help clear infections.
• Reduce the engagement of Fc receptors on immune cells, meaning that the immune system may be slower or less effective in responding to viral threats.
• Correlate with lower neutralizing activity, particularly against newer SARS-CoV-2 variants like Omicron.
These findings suggest that, paradoxically, repeated mRNA vaccination could lead to a form of immune exhaustion or tolerance, making individuals less capable of mounting a robust defense upon reinfection.And this finding is not unprecedented. Large studies by the Cleveland Clinic tracked by TrialSite but not by the pharmaceutical trade press evidenced this very phenomenon in the real world. See “Cleveland Clinic Bombshell: 48.2K Health Care Employee Study—The More Doses with COVID-19 mRNA Vaccine the Higher the Infection Risk.”
Are We Unintentionally Promoting Immune Tolerance?
The persistence of IgG4 raises an even bigger concern, frankly. Could repeated mRNA vaccination train the immune system to tolerate SARS-CoV-2 rather than fight it? This phenomenon is well-documented in chronic infections like HIV and malaria, where a prolonged immune response leads to tolerance rather than elimination of the pathogen. If the same principle applies to SARS-CoV-2, we should certainly need to rethink booster strategies and vaccine formulations.
Moreover, if IgG4 induction is a feature of mRNA technology itself, this could have far-reaching implications for other mRNA vaccines under development for diseases like RSV, influenza, and even cancer. TrialSite’s founder Daniel O’Connor said,“While it’s not been politically correct in the Bidenadministration to probe these vaccines we need to accelerate safety studies, and fast. The hope is under Trump this will change. We can take existing data and design all sorts of studies around expeditiously confirming this hypothesis.”
A shift toward immune tolerance in these contexts could certainly compromise vaccine efficacy in ways we don’t yet fully understand.
Could This Explain Rising Breakthrough Infections?
Breakthrough infections have become a growing concern despite widespread vaccination. Could IgG4 be a missing piece of the puzzle? The study suggests that as IgG4 levels rise, vaccine-induced protection may wane, potentially explaining why some highly vaccinated individuals continue to experience reinfections.
While this remains a theoretical risk, the implications are serious enough to warrant urgent epidemiological studies to examine whether high IgG4 levels correlate with increased susceptibility to reinfection or severe disease.
Beyond COVID-19 and A Bigger Question for mRNA Vaccines
If repeated exposure to mRNA vaccines consistently skews immune responses toward IgG4, this could reshape the entire field of mRNA-based medicine. What does this mean for next-generation vaccines? Should vaccine developers modify formulations to prevent IgG4 dominance? Could IgG4 be a double-edged sword, helping to reduce inflammatory side effects while also dampening immune protection?
Equally concerning is the possibility that prolonged IgG4 elevation could contribute to immune dysregulation. Conditions like IgG4-related disease involve chronic immune activation and fibrosis, raising questions about whether some post-vaccine syndromes could be linked to an unintended shift in immune balance.
Where Do We Go From Here?
This study highlights an unexpected and potentially game-changing effect of repeated mRNA vaccination. While IgG4 is not inherently harmful, its impact on long-term immunity and reinfection risk must be investigated further. Next steps should include:
• Long-term monitoring of vaccinated individuals to assess how IgG4 levels influence reinfection rates and disease severity.
• Epidemiological studies to determine whether IgG4 prevalence correlates with breakthrough infections.
• Vaccine reformulation strategies to ensure sustained protective immunity without excessive immune tolerance.
The rise of IgG4 after repeated mRNA vaccination is a biological twist that demands serious attention. Are we unknowingly training our immune system to tolerate SARS-CoV-2 rather than eliminate it? The answers could reshape not just COVID-19 vaccination strategies but the future of mRNA-based immunology itself.
The study has not been peer-reviewed thus this output needs to be understood with that limitation.
Katie J. Doores, Professor of Viral Immunology & Corresponding Author
Lead Research/Investigator
• Jerry C. H. Tam, Department of Infectious Diseases, School of Immunology & Microbial Sciences, King's College
• Abbie C. Sibayan, Department of Infectious Diseases, School of Immunology & Microbial Sciences, King's College
• Jeffrey Seow, Department of Infectious Diseases, School of Immunology & Microbial Sciences, King's College
• Carl Graham, Department of Infectious Diseases, School of Immunology & Microbial Sciences, King's College
• Ashwini Kurshan, Department of Infectious Diseases, School of Immunology & Microbial Sciences, King's College
• Blair Merrick, Centre for Clinical Infection and Diagnostics Research, Department of Infectious Diseases, Guy’s and 9 St Thomas’ NHS Foundation Trust, London
• Richard J. Stanton, Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, United Kingdom
• Katie J. Doores, Department of Infectious Diseases, School of Immunology & Microbial Sciences, King's College; Corresponding Author
When a short ineffective and hard to call a clinical trial has the FDA giving an illegal EUA for an untested combination of ingredients, what we can expect is a dangerous gene therapy mRNA not proven safe or effective jab. When millions have died and millions of others injured that listened and took the jab, isn’t it time to reevaluate any EUA approvals ever again? I think most citizens know what was done now, a risky, hazardous, unsafe jab was mandated by a group of evil control freaks. We’ve been poisoned intentionally. That’s pretty scary folks. It should have never happened and we need to be ensured it never happens again. Our freedoms were taken away from us, but the way it was done will be reckoned by a high source.
" Long-term monitoring of vaccinated individuals to assess how IgG4 levels influence reinfection rates and disease severity."
Yeah, that will result in "quarterly annual checkups from your doctor" rather than just "yearly."'
"Vaccine reformulation strategies to ensure sustained protective immunity without excessive immune tolerance."
So... more vaxxines to counter the side effects of the old vaccines? Yeah, I can see that happening.
Profit> human life